Concise total synthesis of (+)-asperazine A and (+)-pestalazine B
نویسندگان
چکیده
منابع مشابه
Concise total synthesis and structural revision of (+)-pestalazine B.
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline as the key step. Although its structure was confirmed by X-ray analysis, the spectroscopic data did not match those of the natural product. The versatility of the methodology allowed the prepara...
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The tetranortriterpene cipadonoid B was efficiently constructed from synthetic azedaralide in a one-pot cascade, via the underutilised ketal-Claisen rearrangement.
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The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel-Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3'-indolyl)hexahydropyrroloindole substructure, a molecular foundation present in a significant subset of epipolythiodiketopiperazine natural alkaloids. Our first-gen...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2018
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c7ob02985c